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This teaching unit represents a completely new set of images that illustrate the physiology and pathophysiology of pancreatic function and the causes, diagnosis and management of acute and chronic pancreatitis. The outstanding photographs, micrographs, illustrations and movies explain important concepts in our understanding of how the pancreas functions and serve to add a scientific basis to the and other conditions affecting this vital organ. Images, including graphic representations of data from key studies, are accompanied by explanatory legends that contain recent literature citations, thereby providing a unique teaching and self-educational resource. The senior author, Fred Gorelick, MD, is Professor of Medicine and Cell Biology, Yale University School of Medicine, New Haven, CT.
GTP Pancreatitis is separated into the following sections: Part 1: Pancreatic physiology and biology; Part 2: Acute pancreatitis I; Part 3: Acute pancreatitis II; Part 4: Chronic pancreatitis; Part 5: Pancreatic disease cases including acute pancreatitis, chronic pancreatitis, and pancreatic neoplasms. Moreover, two movies are included: (1) Normal ERCP and (2) ERCP with papillotomy and extraction of common duct stones.
Fred Gorelick is Professor of Medicine (Digestive Diseases) and Cell Biology at Yale University School of Medicine, New Haven, CT. Dr. Gorelick did GI Fellowship at Yale University and joined the Yale Faculty in 1979. He received research training with James D. Jamieson and Paul Greengard. Dr. Gorelick studies the mechanisms of pathologic zymogen activation in the pancreatic acinar cell, cell signaling, and intracellular targeting. His research is supported by grants from the Department of Veterans Affairs and National Institutes of Health.
Dr. Stephen Pandol is Professor of Medicine at UCLA. Dr. Pandol did his GI clinical Fellowship at UCLA with Jon Isenberg and received his research training at NIH with Jerry Gardner and Robert Jensen. He joined the faculty at UCSD in 1982 and moved to UCLA and the Greater Los Angeles Veterans Health Care System in 1996. Dr. Pandol studies the cellular mechanisms of pancreatitis and pancreatic cancer and is particularly interested in mechanisms of inflammation and cell death in these disorders. Dr. Pandol`s research is supported by grants from the Department of Veterans Affairs and NIH.
Dr. Mark Topazian is Associate Professor of Medicine at Mayo College of Medicine in Rochester, MN. Dr. Topazian did his GI training at UCSF and was on the faculty at the Yale School of Medicine until 2003. Dr. Topazian studies clinical issues related to the endoscopic and medical diagnosis and treatment of pancreatic and biliary tract disease.
Dr. Tooru Shimosegawa is Professor of Medicine (Gastroenterology) at Tohoku University Graduate School of Medcine. Dr. Shimosegawa did GI Fellowship and received his research training at Tohoku University School of Medicine under the direction of former Profs. Yoshio Goto and Takayoshi Toyota. He joined the faculty at Tohoku Univerisity School of Medicine in 1989. Dr. Shimosegawa studies the mechanism of MOF in severe acute pancreatitis and the pathogenesis and patho-physiology of chronic pancreatitis.
Dr. Akihiko Satoh is Assistant Professor of Medicine (Gastroenterology) at Tohoku University Graduate School of Medcine. Dr. Satoh did GI Fellowship and received his research training at Tohoku University School of Medicine under the direction of Takayoshi Toyota and Tooru Shimosegawa. He received research training at UCLA with Stephen Pandol and Anna Gukovskaya from 2002 to 2005. Dr. Satoh studies the patho-physiology of acute pancreatitis.
Jerry Schoendorf, MAMS
Chapel Hill, NC
The authors thank the following for reviewing the content of this unit and for many helpful suggestions: Minoti Apte, Peter Bonis, Peter Green, Christopher Marino, Robin Rutherford, Mark Sawicki, Carol Semrad, Stuart Spechler, Michael Steer, Helen Raybould and Jeremy Wilson. We thank Helen Shields for providing the template for clinical cases and for her helpful comments. We wish to give special recognition to David Alpers and Jean-Pierre Raufman for their leadership, enthusiastic support and tireless efforts to help make this an accurate and valued educational tool. We also acknowledge the contributions by authors of previous AGA slide sets on pancreatic physiology and pancreatitis.
This GTP unit is dedicated to Kenneth Barwick (1947 - 2001). Ken was a pathologist at Yale University School of Medicine and later in Jacksonville, Florida at the Mayo Clinic and Baptist Medical Center. He contributed to the training of many physicians, including gastroenterologists. Ken provided much of the pathology content of this unit. With this dedication we recognize his great contributions as an educator, physician and friend.
May 30, 2005