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Pancreatitis (Japanese Version)

Slide 293 of 393

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Etiologies of chronic pancreatitis
In Western countries, the most common etiology of chronic pancreatitis is alcohol abuse. In a growing number of patients, inherited causes are identified. Inherited conditions that predispose to chronic pancreatitis include mutations in the CFTR gene that cause cystic fibrosis, mutations in the trypsinogen gene that cause hereditary pancreatitis, and familial hypertriglyceridemia. In some equatorial countries, such as India, over 25% of chronic pancreatitis has been attributed to a disease that tends occur at a young age with extensive calcification called tropical or fibrocalculous pancreatitis.

スライド290
慢性膵炎の成因。
西欧諸国において慢性膵炎の最も多い成因は飲酒である。多くの症例で遺伝的な成因についても解明が進んでいる。慢性膵炎に罹患しやすい遺伝的素因としては、嚢胞性線維症の原因であるCFTR遺伝子変異、遺伝性膵炎の原因となるトリプシノーゲン遺伝子変異、家族性高トリグリセリド血症などが含まれる。インドのような赤道付近の諸国では、慢性膵炎の25%以上が熱性あるいは fibrocalculous pancreatitisと称される、若年発症で広範な石灰化を伴う疾患によるものである。