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Slide 175 of 368
|Slide 175 |
|Interferon (IFN) treatment of chronic hepatitis D |
|End of treatment virological response, defined as loss of HDV RNA by hybridization assay, was observed in 71%, 36%, and 0 in the 3 groups that received IFN 9 MU tiw, IFN 3 MU tiw or no treatment, respectively (p=0.004 between high dose IFN and control). Six months after cessation of treatment, virological response dropped to 43%, 14%, and 8%, respectively (p=0.048 between high dose IFN and control). During longer follow up of a mean of 32 (range 24-48) months, all had a virological relapse and none had a sustained virological response. However, histological improvement was maintained in the group that received high dose IFN. |
|Farci P, Mandas A, Coiana A, et al. Treatment of chronic hepatitis D with interferon alfa-2a. New Engl J Med 1994;330:88-94. |