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Pancreatic Physiology and Pancreatitis

Slide 157 of 464

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Endoplasmic Reticulum (ER) Stress
This is an electron micrograph of the basal portion of an acinar cell after stimulation with a supraphysiologic dose of the cholinergic agent, carbachol after a period of fasting in the guinea pig. The image shows that the proteins in the ER have aggregated into masses of material in the ER. This situation likely resulted from alterations in the proteins of the ER leading to misfolding followed by aggregation between proteins. These alterations can result from secondary modifications of the proteins due to cellular stresses. The aggregates will turn on the UPR.

Photomicrograph courtesy of James Jamieson, Yale University.